DDX10 explained

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.^{[1] [2]}

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.

Further reading

• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Andersen JS, Lam YW, Leung AK . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wang SC, Lien HC, Xia W . Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. . Cancer Cell . 6 . 3 . 251–61 . 2004 . 15380516 . 10.1016/j.ccr.2004.07.012 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Andersen JS, Lyon CE, Fox AH . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . etal. free . 2002CBio...12....1A .
• Nakao K, Nishino M, Takeuchi K . Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome. . Intern. Med. . 39 . 5 . 412–5 . 2000 . 10830185 . 10.2169/internalmedicine.39.412 . etal. free .
• Zuber J, Tchernitsa OI, Hinzmann B . A genome-wide survey of RAS transformation targets. . Nat. Genet. . 24 . 2 . 144–52 . 2000 . 10655059 . 10.1038/72799 . 21887748 . etal.
• Ikeda T, Ikeda K, Sasaki K . The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. . Int. J. Hematol. . 69 . 3 . 160–4 . 1999 . 10222653 . etal.
• Liang WQ, Clark JA, Fournier MJ . The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein. . Mol. Cell. Biol. . 17 . 7 . 4124–32 . 1997 . 9199348 . 10.1128/mcb.17.7.4124. 232266 .
• Arai Y, Hosoda F, Kobayashi H . The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. . Blood . 89 . 11 . 3936–44 . 1997 . 9166830 . 10.1182/blood.V89.11.3936. etal. free .

Notes and References

1. Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G . A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23 . Genomics . 33 . 2 . 199–206 . Jan 1997 . 8660968 . 10.1006/geno.1996.0184 .
2. Web site: Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.