DDT (gene) explained

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.^{[1] [2] [3]}

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.

See also

• Macrophage migration inhibitory factor domain

Further reading

• Hochstrasser DF, Frutiger S, Paquet N . Human liver protein map: a reference database established by microsequencing and gel comparison. . Electrophoresis . 13 . 12 . 992–1001 . 1993 . 1286669 . 10.1002/elps.11501301201 . 23518983 . etal.
• Odh G, Hindemith A, Rosengren AM . Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole. . Biochem. Biophys. Res. Commun. . 197 . 2 . 619–24 . 1994 . 8267597 . 10.1006/bbrc.1993.2524 . etal.
• Esumi N, Budarf M, Ciccarelli L . Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF. . Mamm. Genome . 9 . 9 . 753–7 . 1999 . 9716662 . 10.1007/s003359900858 . 24034990 . etal.
• Sugimoto H, Taniguchi M, Nakagawa A . Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. . Biochemistry . 38 . 11 . 3268–79 . 1999 . 10079069 . 10.1021/bi982184o . etal.
• Dunham I, Shimizu N, Roe BA . The DNA sequence of human chromosome 22. . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . etal. free .
• Lubetsky JB, Dios A, Han J . The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. . J. Biol. Chem. . 277 . 28 . 24976–82 . 2002 . 11997397 . 10.1074/jbc.M203220200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Sonesson B, Rosengren E, Hansson AS, Hansson C . UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor. . Exp. Dermatol. . 12 . 3 . 278–82 . 2004 . 12823441 . 10.1034/j.1600-0625.2003.120307.x . 12494872 .
• Collins JE, Wright CL, Edwards CA . A genome annotation-driven approach to cloning the human ORFeome. . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . etal . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M . Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation . Biochem Biophys Res Commun . 243 . 2 . 538–44 . Mar 1998 . 9480844 . 10.1006/bbrc.1998.8123 .
2. Coggan M, Whitbread L, Whittington A, Board P . Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex . 334 . Biochem J . (Pt 3) . 617–23 . Nov 1998 . 3 . 9729470 . 1219731 . 10.1042/bj3340617.
3. Web site: Entrez Gene: DDT D-dopachrome tautomerase.