DDT-dehydrochlorinase explained

DDT-dehydrochlorinase
Ec Number:	4.5.1.1
Cas Number:	9031-20-3
Go Code:	0018833

The enzyme DDT-dehydrochlorinase (EC 4.5.1.1) catalyzes the reaction

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane

\rightleftharpoons 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride

This enzyme belongs to the family of lyases, specifically the class of carbon-halide lyases. The systematic name of this enzyme class is 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]. Other names in common use include DDT-ase, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase, dehydrohalogenase, and DDTase.

References

• LIPKE H, KEARNS CW . 1959 . DDT dehydrochlorinase. I. Isolation, chemical properties, and spectrophotometric assay . J. Biol. Chem. . 234 . 2123 - 8 . 13673024 . 8 . 10.1016/S0021-9258(18)69877-1 . free .
• LIPKE H, KEARNS CW . 1959 . DDT dehydrochlorinase. II. Substrate and cofactor specificity . J. Biol. Chem. . 234 . 2129 - 32 . 13673025 . 8 . 10.1016/S0021-9258(18)69878-3 . free .
• Moorefield HH . 1956 . Purification of DDT-dehydrochlorinase from resistant houseflies . Contr. Boyce Thompson Inst. . 18 . 303 - 310 .