DDO (gene) explained

D-aspartate oxidase is an enzyme that is encoded by the DDO gene.^{[1] [2]}

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two (or four, according to) transcript variants encoding different isoforms have been found for this gene.

Further reading

• Barker RF, Hopkinson DA . The genetic and biochemical properties of the D-amino acid oxidases in human tissues . Ann. Hum. Genet. . 41 . 1 . 27–42 . 1977 . 21608 . 10.1111/j.1469-1809.1977.tb01959.x . 40488767 .
• Van Veldhoven PP, Brees C, Mannaerts GP . D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man . Biochim. Biophys. Acta . 1073 . 1 . 203–8 . 1991 . 1991137 . 10.1016/0304-4165(91)90203-S.
• Nagasaki H . Gender-related differences of mouse liver D-aspartate oxidase in the activity and response to administration of D-aspartate and peroxisome proliferators . Int. J. Biochem. . 26 . 3 . 415–23 . 1994 . 8187937 . 10.1016/0020-711X(94)90062-0 .
• Simonic T . cDNA cloning and expression of the flavoprotein D-aspartate oxidase from bovine kidney cortex . Biochem. J. . 322 . 3. 729–35 . 1997 . 9148742 . 10.1042/bj3220729. 1218248 . vanc. Duga S . Negri A . 3 . Tedeschi . G . Malcovati . M . Tenchini . ML . Ronchi . S .
• Amery L . C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal . Biochem. J. . 336 . 2. 367–71 . 1999 . 9820813 . 10.1042/bj3360367. 1219880 . vanc. Brees C . Baes M . 3 . Setoyama . C . Miura . R . Mannaerts . GP . Van Veldhoven . PP .
• Zaar K . Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain . J. Comp. Neurol. . 450 . 3 . 272–82 . 2002 . 12209855 . 10.1002/cne.10320 . vanc. Köst HP . Schad A . 3 . Völkl . Alfred . Baumgart . Eveline . Fahimi . H. Dariush . 24459809 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Mungall AJ . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . vanc. Palmer SA . Sims SK . 3 . Edwards . C. A. . Ashurst . J. L. . Wilming . L. . Jones . M. C. . Horton . R. . Hunt . S. E. . 2003Natur.425..805M . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Setoyama C, Miura R . Structural and functional characterization of the human brain D-aspartate oxidase . J Biochem . 121 . 4 . 798–803 . Jul 1997 . 9163533 . 10.1093/oxfordjournals.jbchem.a021655.
2. Web site: Entrez Gene: DDO D-aspartate oxidase.