DCUN1D1 explained

DCN1-like protein 1 is a protein that in humans is encoded by the DCUN1D1 gene.^{[1] [2] [3]}

DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells.^{[4] [5] [6]}

Interactions

DCUN1D1 has been shown to interact with:

• CAND1,^[7]
• CUL1,^[7]
• CUL2,^[7]
• CUL3^[7] and
• RBX1.^[7]

Further reading

• Sarkaria IS, Pham D, Ghossein RA, Talbot SG, Hezel M, Dudas ME, Ebright MI, Chuai S, Memoli N, Venkatraman ES, Miller VA, Kris MG, Zakowski MF, Rusch VW, Singh B . SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma . The Annals of Thoracic Surgery . 78 . 5 . 1734–41 . Nov 2004 . 15511464 . 10.1016/j.athoracsur.2004.05.056 . free .
• Estilo CL, O-Charoenrat P, Ngai I, Patel SG, Reddy PG, Dao S, Shaha AR, Kraus DH, Boyle JO, Wong RJ, Pfister DG, Huryn JM, Zlotolow IM, Shah JP, Singh B . The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue . Clinical Cancer Research . 9 . 6 . 2300–6 . Jun 2003 . 12796399 .
• Talbot SG, O-charoenrat P, Sarkaria IS, Ghossein R, Reddy P, Ngai I, Cordeiro CN, Wong RJ, Kris MG, Rusch VW, Singh B . Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A . Annals of Surgical Oncology . 11 . 5 . 530–4 . May 2004 . 15123463 . 10.1245/ASO.2004.03.014 . 7962781 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . Jul 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Jacques C, Baris O, Prunier-Mirebeau D, Savagner F, Rodien P, Rohmer V, Franc B, Guyetant S, Malthiery Y, Reynier P . Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors . The Journal of Clinical Endocrinology and Metabolism . 90 . 4 . 2314–20 . Apr 2005 . 15623817 . 10.1210/jc.2004-1337 . 7907994 .
• Sarkaria IS, Stojadinovic A, Talbot SG, Hoos A, Dudas ME, Brennan MF, Ghossein RA, Singh B . Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas . Surgery . 136 . 6 . 1122–8 . Dec 2004 . 15657565 . 10.1016/j.surg.2004.06.041 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B . Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas . Cancer Research . 66 . 19 . 9437–44 . Oct 2006 . 17018598 . 10.1158/0008-5472.CAN-06-2074 . free .

Notes and References

1. Mas C, Bourgeois F, Bulfone A, Levacher B, Mugnier C, Simonneau M . Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16 . Genomics . 65 . 1 . 70–4 . Apr 2000 . 10777668 . 10.1006/geno.2000.6126 .
2. Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M . The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae . Nature . 435 . 7046 . 1257–61 . Jun 2005 . 15988528 . 10.1038/nature03662 . 2005Natur.435.1257K . 4328225 .
3. Web site: Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae).
4. Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B . SCCRO promotes glioma formation and malignant progression in mice . Neoplasia . 12 . 6 . 476–84 . Jun 2010 . 20563250 . 2887088 . 10.1593/neo.10202.
5. Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B . Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas . Cancer Research . 66 . 19 . 9437–44 . Oct 2006 . 17018598 . 10.1158/0008-5472.CAN-06-2074 . free .
6. Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H . Identification of druggable cancer driver genes amplified across TCGA datasets . PLOS ONE . 9 . 5 . e98293 . 2014 . 24874471 . 4038530 . 10.1371/journal.pone.0098293 . 2014PLoSO...998293C . free .
7. Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B . SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation . The Journal of Biological Chemistry . 283 . 48 . 33211–20 . Nov 2008 . 18826954 . 2586271 . 10.1074/jbc.M804440200 . free .