DCP2 explained

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.^{[1] [2] [3]}

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]

Interactions

DCP2 has been shown to interact with DCP1A^[4] and UPF1.^{[2] [5]}

Further reading

• Ueno K, Kumagai T, Kijima T, Kishimoto T, Hosoe S . Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer . Human Genetics . 102 . 1 . 63–68 . January 1998 . 9490301 . 10.1007/s004390050655 . 36201527 .
• van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Séraphin B . Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures . The EMBO Journal . 21 . 24 . 6915–6924 . December 2002 . 12486012 . 139098 . 10.1093/emboj/cdf678 .
• Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T . The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci . RNA . 8 . 12 . 1489–1501 . December 2002 . 12515382 . 1370355 . 10.1017/S1355838202021726 .
• Grzymski EC . Visualizing an mRNA destruction line . Nature Structural Biology . 10 . 6 . 416 . June 2003 . 12768200 . 10.1038/nsb0603-416 . 40900780 . free .
• Piccirillo C, Khanna R, Kiledjian M . Functional characterization of the mammalian mRNA decapping enzyme hDcp2 . RNA . 9 . 9 . 1138–1147 . September 2003 . 12923261 . 1370477 . 10.1261/rna.5690503 .
• Lejeune F, Li X, Maquat LE . Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities . Molecular Cell . 12 . 3 . 675–687 . September 2003 . 14527413 . 10.1016/S1097-2765(03)00349-6 . free .
• Cougot N, Babajko S, Séraphin B . Cytoplasmic foci are sites of mRNA decay in human cells . The Journal of Cell Biology . 165 . 1 . 31–40 . April 2004 . 15067023 . 2172085 . 10.1083/jcb.200309008 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–1323 . July 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Liu SW, Jiao X, Liu H, Gu M, Lima CD, Kiledjian M . Functional analysis of mRNA scavenger decapping enzymes . RNA . 10 . 9 . 1412–1422 . September 2004 . 15273322 . 1370627 . 10.1261/rna.7660804 .
• Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R . MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies . Nature Cell Biology . 7 . 7 . 719–723 . July 2005 . 15937477 . 1855297 . 10.1038/ncb1274 .
• Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J . Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping . Molecular Cell . 20 . 6 . 905–915 . December 2005 . 16364915 . 10.1016/j.molcel.2005.10.031 . free .
• Wichroski MJ, Robb GB, Rana TM . Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies . PLOS Pathogens . 2 . 5 . e41 . May 2006 . 16699599 . 1458959 . 10.1371/journal.ppat.0020041 . free .
• Chu CY, Rana TM . Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54 . PLOS Biology . 4 . 7 . e210 . July 2006 . 16756390 . 1475773 . 10.1371/journal.pbio.0040210 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Wang Z, Jiao X, Carr-Schmid A, Kiledjian M . The hDcp2 protein is a mammalian mRNA decapping enzyme . Proceedings of the National Academy of Sciences of the United States of America . 99 . 20 . 12663–12668 . October 2002 . 12218187 . 130517 . 10.1073/pnas.192445599 . free . 2002PNAS...9912663W .
2. Lykke-Andersen J . Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay . Molecular and Cellular Biology . 22 . 23 . 8114–8121 . December 2002 . 12417715 . 134073 . 10.1128/MCB.22.23.8114-8121.2002 .
3. Web site: Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae).
4. Lykke-Andersen J . Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay . Molecular and Cellular Biology . 22 . 23 . 8114–8121 . December 2002 . 12417715 . 134073 . 10.1128/MCB.22.23.8114-8121.2002 .
5. Lejeune F, Li X, Maquat LE . Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities . Molecular Cell . 12 . 3 . 675–687 . September 2003 . 14527413 . 10.1016/S1097-2765(03)00349-6 . free .