DCP1A explained

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.^[1]

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.

Interactions

DCP1A has been shown to interact with DCP2^[2] and UPF1.^[2] It has also been shown to colocalize with GW182, and other markers of P-body.^[3] Human DCP1A is heterotrimeric,^[4] and makes contacts with the scaffold EDC3/4.^[5] The Arabidopsis thaliana homolog interacts with the plant specific type XI myosin motor protein.^[6]

Further reading

• Bai RY, Koester C, Ouyang T, Hahn SA, Hammerschmidt M, Peschel C, Duyster J . SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling . Nature Cell Biology . 4 . 3 . 181–190 . March 2002 . 11836524 . 10.1038/ncb753 . 19938060 .
• Callebaut I . An EVH1/WH1 domain as a key actor in TGFbeta signalling . FEBS Letters . 519 . 1–3 . 178–180 . May 2002 . 12023040 . 10.1016/S0014-5793(02)02751-5 . 84499961 . free .
• Lykke-Andersen J . Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay . Molecular and Cellular Biology . 22 . 23 . 8114–8121 . December 2002 . 12417715 . 134073 . 10.1128/MCB.22.23.8114-8121.2002 .
• Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T . The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci . RNA . 8 . 12 . 1489–1501 . December 2002 . 12515382 . 1370355 . 10.1017/S1355838202021726 .
• Leonard D, Ajuh P, Lamond AI, Legerski RJ . hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing . Biochemical and Biophysical Research Communications . 308 . 4 . 793–801 . September 2003 . 12927788 . 10.1016/S0006-291X(03)01486-4 . 10.1.1.539.8359 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–1323 . July 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . 6 . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–12135 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . free . 2004PNAS..10112130B .
• Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R . MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies . Nature Cell Biology . 7 . 7 . 719–723 . July 2005 . 15937477 . 1855297 . 10.1038/ncb1274 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . October 2005 . 16189514 . 10.1038/nature04209 . 4427026 . 2005Natur.437.1173R .
• Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J . Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping . Molecular Cell . 20 . 6 . 905–915 . December 2005 . 16364915 . 10.1016/j.molcel.2005.10.031 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Web site: Entrez Gene: DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae).
2. Lykke-Andersen J . Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay . Molecular and Cellular Biology . 22 . 23 . 8114–8121 . December 2002 . 12417715 . 134073 . 10.1128/MCB.22.23.8114-8121.2002 .
3. Eystathioy T, Jakymiw A, Chan EK, Séraphin B, Cougot N, Fritzler MJ . The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies . RNA . 9 . 10 . 1171–1173 . October 2003 . 13130130 . 1370480 . 10.1261/rna.5810203 .
4. Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E, Weichenrieder O . 6 . DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa . Proceedings of the National Academy of Sciences of the United States of America . 106 . 51 . 21591–21596 . December 2009 . 19966221 . 2789166 . 10.1073/pnas.0909871106 . free . 2009PNAS..10621591T .
5. Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O . 6 . A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting . Molecular and Cellular Biology . 27 . 24 . 8600–8611 . December 2007 . 17923697 . 2169425 . 10.1128/MCB.01506-07 .
6. Steffens A, Jaegle B, Tresch A, Hülskamp M, Jakoby M . Processing-body movement in Arabidopsis depends on an interaction between myosins and DECAPPING PROTEIN1 . Plant Physiology . 164 . 4 . 1879–1892 . April 2014 . 24525673 . 3982750 . 10.1104/pp.113.233031 . free .