DCHS2 explained

Protein dachsous homolog 2, also known as protocadherin-23 (PCDH23) or cadherin-27 (CDH27), is a protein that in humans is encoded by the DCHS2 gene.^{[1] [2]}

DCHS2 has been implicated in the nose angle (how much a nose is upturned).^[3] As well as facial genetics ^{[4] [5]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .

Notes and References

1. Web site: Entrez Gene: dachsous 2 (Drosophila).
2. Hoeng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y . Identification of new human cadherin genes using a combination of protein motif search and gene finding methods . Journal of Molecular Biology . 337 . 2 . 307–317 . March 2004 . 15003449 . 10.1016/j.jmb.2004.01.026 .
3. Adhikari K, Fuentes-Guajardo M, Quinto-Sánchez M, Mendoza-Revilla J, Camilo Chacón-Duque J, Acuña-Alonzo V, Jaramillo C, Arias W, Lozano RB, Pérez GM, Gómez-Valdés J, Villamil-Ramírez H, Hunemeier T, Ramallo V, Silva de Cerqueira CC, Hurtado M, Villegas V, Granja V, Gallo C, Poletti G, Schuler-Faccini L, Salzano FM, Bortolini MC, Canizales-Quinteros S, Cheeseman M, Rosique J, Bedoya G, Rothhammer F, Headon D, González-José R, Balding D, Ruiz-Linares A . A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation . Nature Communications . 7 . 11616 . May 2016 . 27193062 . 4874031 . 10.1038/ncomms11616 . 2016NatCo...711616A .
4. Richmond S, Howe LJ, Lewis S, Stergiakouli E, Zhurov A . Facial Genetics: A Brief Overview . Frontiers in Genetics . 9 . 462 . 2018 . 30386375 . 6198798 . 10.3389/fgene.2018.00462 . free .
5. Web site: Firger J . Your nose--Big or small--is shaped by your DNA. . 19 May 2016 .