DCG-IV explained

DCG-IV is a research drug which acts as a group-selective agonist for the group II metabotropic glutamate receptors (mGluR_2/3).^[1] It has potent neuroprotective and anticonvulsant effects in animal studies,^{[2] [3] [4] [5]} as well as showing anti-Parkinsonian effects,^{[6] [7]} but also impairs the formation of memories.^{[8] [9]}

Notes and References

1. Ishida M, Saitoh T, Shimamoto K, Ohfune Y, Shinozaki H . A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord . . 109 . 4 . 1169–77 . August 1993 . 8401927 . 2175774 . 10.1111/j.1476-5381.1993.tb13745.x.
2. Bruno V, Copani A, Battaglia G, Raffaele R, Shinozaki H, Nicoletti F . Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death . European Journal of Pharmacology . 256 . 1 . 109–12 . April 1994 . 7517889 . 10.1016/0014-2999(94)90624-6.
3. Yoshioka H, Sugita M, Kinouchi H . Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia . Neuroscience Letters . 461 . 3 . 266–70 . September 2009 . 19549561 . 10.1016/j.neulet.2009.06.056 . 23564621 .
4. Attwell PJ, Singh Kent N, Jane DE, Croucher MJ, Bradford HF . Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV) . Brain Research . 805 . 1–2 . 138–43 . September 1998 . 9733953 . 10.1016/S0006-8993(98)00698-2. 10771399 .
5. Fei Z, Zhang X, Bai HM, Jiang XF, Wang XL . Metabotropic glutamate receptor antagonists and agonists: potential neuroprotectors in diffuse brain injury . Journal of Clinical Neuroscience . 13 . 10 . 1023–7 . December 2006 . 17113985 . 10.1016/j.jocn.2005.11.042 . 6959171 .
6. Dawson L, Chadha A, Megalou M, Duty S . The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat . British Journal of Pharmacology . 129 . 3 . 541–6 . February 2000 . 10711353 . 1571875 . 10.1038/sj.bjp.0703105 .
7. Venero JL, Santiago M, Tomás-Camardiel M, Matarredona ER, Cano J, Machado A . DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury . Neuroscience . 113 . 4 . 857–69 . 2002 . 12182892 . 10.1016/S0306-4522(02)00232-4. 23686620 . free .
8. Huang LQ, Rowan MJ, Anwyl R . mGluR II agonist inhibition of LTP induction, and mGluR II antagonist inhibition of LTD. induction, in the dentate gyrus in vitro . NeuroReport . 8 . 3 . 687–93 . February 1997 . 9106748 . 10.1097/00001756-199702100-00022. 42513317 .
9. Sato T, Tanaka K, Ohnishi Y, Teramoto T, Irifune M, Nishikawa T . Inhibitory effects of group II mGluR-related drugs on memory performance in mice . Physiology & Behavior . 80 . 5 . 747–58 . February 2004 . 14984810 . 10.1016/j.physbeh.2003.12.010 . 33433968 .