DCAF15 explained

DDB1 and CUL4 associated factor 15 is a protein that in humans is encoded by the DCAF15 gene.[1]

DCAF15 forms a complex with CUL4A or CUL4B that has E3 ubiquitin ligase activity and is responsible for the proteasome degradation of certain proteins.[2]

Notes and References

  1. Web site: Entrez Gene: DDB1 and CUL4 associated factor 15 .
  2. Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D . Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15 . Science . 356 . 6336 . eaal3755. April 2017 . 28302793 . 10.1126/science.aal3755 . 3885214 .

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