DBR1 explained

Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene.^{[1] [2]}

The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.[supplied by OMIM]

Further reading

• Chapman KB, Boeke JD . Isolation and characterization of the gene encoding yeast debranching enzyme. . Cell . 65 . 3 . 483–92 . 1991 . 1850323 . 10.1016/0092-8674(91)90466-C . 39225964 .
• Arenas J, Hurwitz J . Purification of a RNA debranching activity from HeLa cells. . J. Biol. Chem. . 262 . 9 . 4274–9 . 1987 . 10.1016/S0021-9258(18)61343-2 . 2435736 . free .
• Martin A, Schneider S, Schwer B . Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome. . J. Biol. Chem. . 277 . 20 . 17743–50 . 2002 . 11886864 . 10.1074/jbc.M200762200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ye Y, De Leon J, Yokoyama N . DBR1 siRNA inhibition of HIV-1 replication. . Retrovirology . 2 . 63 . 2006 . 16232320 . 10.1186/1742-4690-2-63 . 1266399 . etal . free .
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

Notes and References

1. Kim JW, Kim HC, Kim GM, Yang JM, Boeke JD, Nam K . Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants . Nucleic Acids Res . 28 . 18 . 3666–73 . Sep 2000 . 10982890 . 110720 . 10.1093/nar/28.18.3666 .
2. Web site: Entrez Gene: DBR1 debranching enzyme homolog 1 (S. cerevisiae).