DBN1 explained

Drebrin is a protein that in humans is encoded by the DBN1 gene.^{[1] [2]}

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.

Further reading

• Shirao T . The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review . J. Biochem. . 117 . 2 . 231–6 . 1995 . 7608104 . 10.1093/jb/117.2.231 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Harigaya Y, Shoji M, Shirao T, Hirai S . Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease . J. Neurosci. Res. . 43 . 1 . 87–92 . 1996 . 8838578 . 10.1002/jnr.490430111 . 40336358 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Mammoto A, Sasaki T, Asakura T . Interactions of drebrin and gephyrin with profilin . Biochem. Biophys. Res. Commun. . 243 . 1 . 86–9 . 1998 . 9473484 . 10.1006/bbrc.1997.8068 . etal.
• Hayashi K, Ishikawa R, Kawai-Hirai R . Domain analysis of the actin-binding and actin-remodeling activities of drebrin . Exp. Cell Res. . 253 . 2 . 673–80 . 2000 . 10585290 . 10.1006/excr.1999.4663 . etal.
• Peitsch WK, Grund C, Kuhn C . Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells . Eur. J. Cell Biol. . 78 . 11 . 767–78 . 2000 . 10604653 . 10.1016/s0171-9335(99)80027-2. etal.
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Simpson JC, Wellenreuther R, Poustka A . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 . etal.
• Kobayashi S, Shirao T, Sasaki T . Drebrin expression is increased in spinal motoneurons of rats after axotomy . Neurosci. Lett. . 311 . 3 . 165–8 . 2001 . 11578820 . 10.1016/S0304-3940(01)02155-3 . 15935730 .
• Shim KS, Lubec G . Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome . Neurosci. Lett. . 324 . 3 . 209–12 . 2002 . 12009525 . 10.1016/S0304-3940(02)00210-0 . 20834151 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T . Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons . Mol. Cell. Neurosci. . 22 . 2 . 188–201 . 2003 . 12676529 . 10.1016/S1044-7431(03)00037-X . 38323844 .
• Peitsch WK, Hofmann I, Endlich N . Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli . J. Am. Soc. Nephrol. . 14 . 6 . 1452–63 . 2003 . 12761245 . 10.1097/01.ASN.0000069222.63700.DE . etal. free .
• Salazar MA, Kwiatkowski AV, Pellegrini L . Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton . J. Biol. Chem. . 278 . 49 . 49031–43 . 2004 . 14506234 . 10.1074/jbc.M308104200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .

Notes and References

1. Toda M, Shirao T, Minoshima S, Shimizu N, Toya S, Uyemura K . Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene . Biochem Biophys Res Commun . 196 . 1 . 468–72 . Nov 1993 . 8216329 . 10.1006/bbrc.1993.2273 .
2. Web site: Entrez Gene: DBN1 drebrin 1.