DBF4 explained

Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.^{[1] [2] [3]}

Interactions

DBF4 has been shown to interact with:

• Cell division cycle 7-related protein kinase,^{[1] [4]}
• MCM3,
• MCM7,
• ORC2L,^[5] and
• ORC6L.^[5]

Further reading

• Jiang W, McDonald D, Hope TJ, Hunter T . Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication . The EMBO Journal . 18 . 20 . 5703–13 . Oct 1999 . 10523313 . 1171637 . 10.1093/emboj/18.20.5703 .
• Yamada M, Sato N, Taniyama C, Ohtani K, Arai K, Masai H . A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase . The Journal of Biological Chemistry . 277 . 31 . 27668–81 . Aug 2002 . 12015319 . 10.1074/jbc.M202884200 . free .
• Wu X, Lee H . Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements . Oncogene . 21 . 51 . 7786–96 . Nov 2002 . 12420215 . 10.1038/sj.onc.1205914 . 745681 .
• Duncker BP, Shimada K, Tsai-Pflugfelder M, Pasero P, Gasser SM . An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing . Proceedings of the National Academy of Sciences of the United States of America . 99 . 25 . 16087–92 . Dec 2002 . 12441400 . 138569 . 10.1073/pnas.252093999 . 2002PNAS...9916087D . free .
• Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J . An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication . Molecular Cell . 11 . 1 . 203–13 . Jan 2003 . 12535533 . 10.1016/S1097-2765(02)00799-2 . free .
• Kneissl M, Pütter V, Szalay AA, Grummt F . Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells . Journal of Molecular Biology . 327 . 1 . 111–28 . Mar 2003 . 12614612 . 10.1016/S0022-2836(03)00079-2 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–23 . Jul 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Schnepp RW, Hou Z, Wang H, Petersen C, Silva A, Masai H, Hua X . Functional interaction between tumor suppressor menin and activator of S-phase kinase . Cancer Research . 64 . 18 . 6791–6 . Sep 2004 . 15374998 . 10.1158/0008-5472.CAN-04-0724 . 17231177 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Gérard A, Koundrioukoff S, Ramillon V, Sergère JC, Mailand N, Quivy JP, Almouzni G . The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen . EMBO Reports . 7 . 8 . 817–23 . Aug 2006 . 16826239 . 1525143 . 10.1038/sj.embor.7400750 .
• Tsuji T, Ficarro SB, Jiang W . Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells . Molecular Biology of the Cell . 17 . 10 . 4459–72 . Oct 2006 . 16899510 . 1635350 . 10.1091/mbc.E06-03-0241 .
• Heffernan TP, Unsal-Kaçmaz K, Heinloth AN, Simpson DA, Paules RS, Sancar A, Cordeiro-Stone M, Kaufmann WK . Cdc7-Dbf4 and the human S checkpoint response to UVC . The Journal of Biological Chemistry . 282 . 13 . 9458–68 . Mar 2007 . 17276990 . 1839878 . 10.1074/jbc.M611292200 . free .

Notes and References

1. Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H . A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells . Molecular and Cellular Biology . 19 . 7 . 5083–95 . Jul 1999 . 10373557 . 84351 . 10.1128/MCB.19.7.5083.
2. Lepke M, Pütter V, Staib C, Kneissl M, Berger C, Hoehn K, Nanda I, Schmid M, Grummt F . Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes . Molecular & General Genetics . 262 . 2 . 220–9 . Sep 1999 . 10517317 . 10.1007/s004380051078 . 24878962 .
3. Web site: Entrez Gene: DBF4 DBF4 homolog (S. cerevisiae).
4. Jiang W, McDonald D, Hope TJ, Hunter T . Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication . The EMBO Journal . 18 . 20 . 5703–13 . Oct 1999 . 10523313 . 1171637 . 10.1093/emboj/18.20.5703 .
5. Kneissl M, Pütter V, Szalay AA, Grummt F . Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells . Journal of Molecular Biology . 327 . 1 . 111–28 . Mar 2003 . 12614612 . 10.1016/s0022-2836(03)00079-2.