DAZAP2 explained

DAZ-associated protein 2 is a protein that in humans is encoded by the DAZAP2 gene.^{[1] [2] [3]}

Function

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region and is deleted in many azoospermic and severely oligospermic men. It is thought that the Y chromosomal DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL.

Interactions

DAZAP2 has been shown to interact with DAZ1.^[4]

Further reading

• Hamilton MH, Tcherepanova I, Huibregtse JM, McDonnell DP . Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates . J. Biol. Chem. . 276 . 28 . 26324–31 . 2001 . 11342538 . 10.1074/jbc.M101205200 . free .
• Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH . Sox6 regulation of cardiac myocyte development . Nucleic Acids Res. . 31 . 20 . 5941–8 . 2003 . 14530442 . 219484 . 10.1093/nar/gkg807 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Shi Y, Luo S, Peng J, Huang C, Tan D, Hu W . The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma . Genomics Proteomics Bioinformatics . 2 . 1 . 47–54 . 2004 . 15629043 . 10.1016/s1672-0229(04)02007-8. 5172432 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Shi YW, Shen R, Ren W, Tang LJ, Tan DR, Hu WX . Molecular features and expression of DAZAP2 in human multiple myeloma . Chin. Med. J. . 120 . 19 . 1659–65 . 2007 . 17935665 . 10.1097/00029330-200710010-00003. free .

Notes and References

1. Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH . Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1 . Genomics . 65 . 3 . 266–73 . Aug 2000 . 10857750 . 10.1006/geno.2000.6169 .
2. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S . Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 1 . 5 . 223–9 . 1994 . 7584044 . 10.1093/dnares/1.5.223 . free .
3. Web site: Entrez Gene: DAZAP2 DAZ associated protein 2.
4. Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH . Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1 . Genomics . 65 . 3 . 266–73 . May 2000 . 10857750 . 10.1006/geno.2000.6169 .