DAP (gene) explained

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene.^{[1] [2] [3]}

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.

Further reading

• Levy-Strumpf N, Kimchi A . Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions . Oncogene . 17 . 25 . 3331–40 . 1999 . 9916995 . 10.1038/sj.onc.1202588 . free .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.
• Zougman A, Wiśniewski JR . Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins . J. Proteome Res. . 5 . 4 . 925–34 . 2006 . 16602700 . 10.1021/pr050415p .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Suzuki Y . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . vanc. Yamashita R . Shirota M . 3 . Sakakibara . Y . Chiba . J . Mizushima-Sugano . J . Nakai . K . Sugano . S .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .

Notes and References

1. Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K . Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively . Genomics . 29 . 1 . 305–7 . Feb 1996 . 8530096 . 10.1006/geno.1995.1255 .
2. Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A . Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death . Genes Dev . 9 . 1 . 15–30 . Feb 1995 . 7828849 . 10.1101/gad.9.1.15 . free .
3. Web site: Entrez Gene: DAP death-associated protein.