DAPT (chemical) explained

DAPT is a chemical compound used in the study of the Notch signaling pathway.^[1] DAPT is a γ-secretase inhibitor. It indirectly inhibits Notch, which is a substrate for γ-secretase.^[2]

In a mouse model of Alzheimer's disease, DAPT reduces the levels of beta-amyloid.^[3]

Notes and References

1. 10.1093/embo-reports/kvf124 . 12101103 . 1084181 . A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish . EMBO Reports . 3 . 7 . 688–694 . 2002 . Geling . A. . Steiner . H. . Willem . M. . Bally-Cuif . L. . Haass . C. .
2. Web site: DAPT . .
3. 11145990. 2001. Dovey. H. F.. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. Journal of Neurochemistry. 76. 1. 173–81. John. V.. Anderson. J. P.. Chen. L. Z.. De Saint Andrieu. P.. Fang. L. Y.. Freedman. S. B.. Folmer. B.. Goldbach. E.. Holsztynska. E. J.. Hu. K. L.. Johnson-Wood. K. L.. Kennedy. S. L.. Kholodenko. D.. Knops. J. E.. Latimer. L. H.. Lee. M.. Liao. Z.. Lieberburg. I. M.. Motter. R. N.. Mutter. L. C.. Nietz. J.. Quinn. K. P.. Sacchi. K. L.. Seubert. P. A.. Shopp. G. M.. Thorsett. E. D.. Tung. J. S.. Wu. J.. Yang. S.. 29. 10.1046/j.1471-4159.2001.00012.x. free.