DAPK2 explained

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.^{[1] [2]}

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Gene overexpression induces cell apoptosis. It uses multiple polyadenylation sites.

The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.^[3]

Further reading

• Inbal B, Shani G, Cohen O . Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis . Mol. Cell. Biol. . 20 . 3 . 1044–54 . 2000 . 10629061 . 10.1128/MCB.20.3.1044-1054.2000 . 85221 . etal.
• Shani G, Henis-Korenblit S, Jona G . Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding . EMBO J. . 20 . 5 . 1099–113 . 2001 . 11230133 . 10.1093/emboj/20.5.1099 . 145456 . etal.
• Wong TS, Chang HW, Tang KC . High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients . Clin. Cancer Res. . 8 . 2 . 433–7 . 2002 . 11839660 . etal.
• Chan MW, Chan LW, Tang NL . Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients . Clin. Cancer Res. . 8 . 2 . 464–70 . 2002 . 11839665 . etal.
• Inbal B, Bialik S, Sabanay I . DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death . J. Cell Biol. . 157 . 3 . 455–68 . 2002 . 11980920 . 10.1083/jcb.200109094 . 2173279 . etal.
• Satoh A, Toyota M, Itoh F . DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers . Br. J. Cancer . 86 . 11 . 1817–23 . 2002 . 12087472 . 10.1038/sj.bjc.6600319 . 2375414 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Barrios-Rodiles M, Brown KR, Ozdamar B . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . etal. free .
• Rizzi M, Tschan MP, Britschgi C . The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells . J. Leukoc. Biol. . 81 . 6 . 1599–608 . 2007 . 17347302 . 10.1189/jlb.0606400 . etal. free .

Notes and References

1. Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S . Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity . Oncogene . 18 . 23 . 3471–80 . Jun 1999 . 10376525 . 10.1038/sj.onc.1202701 . 19035227 .
2. Web site: Entrez Gene: DAPK2 death-associated protein kinase 2.
3. New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform. PLOS ONE. 6. 2. e17344. 10.1371/journal.pone.0017344. 21408167. 3050894. 2011. Shoval. Yishay. Berissi. Hanna. Kimchi. Adi. Pietrokovski. Shmuel. 2011PLoSO...617344S. free.