DAOA-AS1 explained

In molecular biology, DAOA-AS1, DAOA antisense RNA 1 (non-protein coding), (formerly known as G30), is a human gene encoding a long non-coding RNA. It was originally identified in a screen for genes associated with schizophrenia.^[1] It is also associated with bipolar disorder and other psychiatric phenotypes.^{[2] [3]} It may regulate the expression of the DAOA gene.

See also

• D-amino acid oxidase activator
• Long non-coding RNA

Further reading

• Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES . Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series . American Journal of Human Genetics . 72 . 5 . 1131–1140 . May 2003 . 12647258 . 1180266 . 10.1086/374822 .
• Wang X, He G, Gu N, Yang J, Tang J, Chen Q, Liu X, Shen Y, Qian X, Lin W, Duan Y, Feng G, He L . Association of G72/G30 with schizophrenia in the Chinese population . Biochemical and Biophysical Research Communications . 319 . 4 . 1281–1286 . Jul 2004 . 15194506 . 10.1016/j.bbrc.2004.05.119 .
• Korostishevsky M, Kaganovich M, Cholostoy A, Ashkenazi M, Ratner Y, Dahary D, Bernstein J, Bening-Abu-Shach U, Ben-Asher E, Lancet D, Ritsner M, Navon R . Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis . Biological Psychiatry . 56 . 3 . 169–176 . Aug 2004 . 15271585 . 10.1016/j.biopsych.2004.04.006 . 36460604 .
• Schumacher J, Abou Jamra R, Becker T, Klopp N, Franke P, Jacob C, Sand P, Fritze J, Ohlraun S, Schulze TG, Rietschel M, Illig T, Propping P, Cichon S, Deckert J, Nöthen MM . Investigation of the DAOA/G30 locus in panic disorder . Molecular Psychiatry . 10 . 5 . 428–429 . May 2005 . 15477870 . 10.1038/sj.mp.4001598 . free .
• Britten RJ . Coding sequences of functioning human genes derived entirely from mobile element sequences . Proceedings of the National Academy of Sciences of the United States of America . 101 . 48 . 16825–16830 . Nov 2004 . 15546984 . 534736 . 10.1073/pnas.0406985101 . 2004PNAS..10116825B . free .
• Zou F, Li C, Duan S, Zheng Y, Gu N, Feng G, Xing Y, Shi J, He L . A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population . Schizophrenia Research . 73 . 2–3 . 257–261 . Mar 2005 . 15653269 . 10.1016/j.schres.2004.01.015 . 31923687 .
• Mulle JG, McDonough JA, Chowdari KV, Nimgaonkar V, Chakravarti A . Evidence for linkage to chromosome 13q32 in an independent sample of schizophrenia families . Molecular Psychiatry . 10 . 5 . 429–431 . May 2005 . 15738936 . 10.1038/sj.mp.4001639 . free .
• Ma J, Qin W, Wang XY, Guo TW, Bian L, Duan SW, Li XW, Zou FG, Fang YR, Fang JX, Feng GY, Gu NF, St Clair D, He L . Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations . Molecular Psychiatry . 11 . 5 . 479–487 . May 2006 . 16402132 . 10.1038/sj.mp.4001788 . free .
• Hong CJ, Hou SJ, Yen FC, Liou YJ, Tsai SJ . Family-based association study between G72/G30 genetic polymorphism and schizophrenia . NeuroReport . 17 . 10 . 1067–1069 . Jul 2006 . 16791105 . 10.1097/01.wnr.0000224763.61959.26 . 2199301 .
• Li D, He L . G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies . Genetics . 175 . 2 . 917–922 . Feb 2007 . 17179078 . 1800627 . 10.1534/genetics.106.061796 .
• Yue W, Liu Z, Kang G, Yan J, Tang F, Ruan Y, Zhang J, Zhang D . Association of G72/G30 polymorphisms with early-onset and male schizophrenia . NeuroReport . 17 . 18 . 1899–1902 . Dec 2006 . 17179866 . 10.1097/WNR.0b013e3280102ed4 . 10.1.1.612.6655 . 14178731 .

Notes and References

1. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellette G, Fortier I, Raelson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J, Konings F, Luyten W, Macciardi F, Sham PC, Straub RE, Weinberger DR, Cohen N, Cohen D, Ouelette G, Realson J . Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia . 6 . Proceedings of the National Academy of Sciences of the United States of America . 99 . 21 . 13675–13680 . Oct 2002 . 12364586 . 129739 . 10.1073/pnas.182412499 . 2002PNAS...9913675C . free .
2. Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES . Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series . American Journal of Human Genetics . 72 . 5 . 1131–1140 . May 2003 . 12647258 . 1180266 . 10.1086/374822 .
3. Abou Jamra R, Schmael C, Cichon S, Rietschel M, Schumacher J, Nöthen MM . The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries? . Schizophrenia Bulletin . 32 . 4 . 599–608 . Oct 2006 . 16914640 . 2632259 . 10.1093/schbul/sbl028 .