Daf-12 Explained
| Nuclear hormone receptor family member daf-12 |
| Organism: | Caenorhabditis elegans |
| Taxid: | 6239 |
| Symbol: | daf-12 |
| Altsymbols: | NR1J1 |
| Entrezgene: | 181263 |
| Refseqmrna: | NM_001029376.5 |
| Refseqprotein: | NP_001024547.1 |
| Uniprot: | G5EFF5 |
| Chromosome: | X |
| Entrezchromosome: | NC_003284.9 |
| Genloc Start: | 10641038 |
| Genloc End: | 10670243 |
The DAF-12 (abnormal dauer formation protein 12) gene encodes the nuclear receptor of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans, with the NRNC Symbol NR1J1 as the homolog of nuclear hormone receptor HR96 (Hr96) in Drosophila melanogaster.[1] DAF-12 has been implicated by Cynthia Kenyon and colleagues in the formation of Dauer larva.[2]
In favorable environments, a cytochrome p450 Daf-9 (Cyp22a1)[3] produce dafachronic acid to binding Daf-12 to initiating downstream gene expression.[4] When in infavorable environments, like starvation, dafachronic acid decreases, Daf-12 will form a complex with co-repressor DIN-1.[5]
References
- Kaur S, Jobling S, Jones CS, Noble LR, Routledge EJ, Lockyer AE . The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: implications for developing new model organisms . . 10 . 4 . e0121259 . 7 April 2015 . 25849443 . 4388693 . 10.1371/journal.pone.0121259 . free . 2015PLoSO..1021259K .
- Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R . A C. elegans mutant that lives twice as long as wild type . . 366 . 6454 . 1993 . 461–464 . 8247153 . 10.1038/366461a0. 1993Natur.366..461K . 4332206 .
- Jia K, Albert PS, Riddle DL. DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity . . 129 . 1 . 221–31 . 2002 . 10.1242/dev.129.1.221 . 11782415 .
- Aguilaniu H, Fabrizio P, Witting M . The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry . . 7 . 12 . 2016 . 26903948 . 4749721 . 10.3389/fendo.2016.00012 . free .
- Bento G, Ogawa A, Sommer RJ . Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution . . 466 . 7305 . 494–7 . July 2010 . 20592728 . 10.1038/nature09164 . 2010Natur.466..494B . 4405326 .
