DACH2 explained

Dachshund homolog 2 is a protein that in humans is encoded by the DACH2 gene.^[1]

Function

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.

Further reading

• Bione S, Rizzolio F, Sala C, Ricotti R, Goegan M, Manzini MC, Battaglia R, Marozzi A, Vegetti W, Dalprà L, Crosignani PG, Ginelli E, Nappi R, Bernabini S, Bruni V, Torricelli F, Zuffardi O, Toniolo D . Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B . Human Reproduction . 19 . 12 . 2759–66 . Dec 2004 . 15459172 . 10.1093/humrep/deh502 . free .
• Poulin F, Nobrega MA, Plajzer-Frick I, Holt A, Afzal V, Rubin EM, Pennacchio LA . In vivo characterization of a vertebrate ultraconserved enhancer . Genomics . 85 . 6 . 774–81 . Jun 2005 . 15885503 . 10.1016/j.ygeno.2005.03.003 . 21888183 .
• Davis RJ, Shen W, Sandler YI, Heanue TA, Mardon G . Characterization of mouse Dach2, a homologue of Drosophila dachshund . Mechanisms of Development . 102 . 1–2 . 169–79 . Apr 2001 . 11287190 . 10.1016/s0925-4773(01)00307-0. free .
• Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML, Koseki H, Kitabayashi I . Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation . The EMBO Journal . 25 . 17 . 3955–65 . Sep 2006 . 16917507 . 1560355 . 10.1038/sj.emboj.7601273 .
• Prueitt RL, Chen H, Barnes RI, Zinn AR . Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes . Cytogenetic and Genome Research . 97 . 1–2 . 32–8 . 2002 . 12438735 . 10.1159/000064052 . 8347100 .

Notes and References

1. Multiple transcript variants encoding different isoforms have been found for this gene.Web site: Entrez Gene: Dachshund homolog 2 (Drosophila). 2012-04-15 .