DAB2IP explained

Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.^{[1] [2] [3]}

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM]

Interactions

DAB2IP has been shown to interact with DAB2.^[4]

Further reading

• Nakajima D, Okazaki N, Yamakawa H . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . etal. free .
• Nagase T, Kikuno R, Hattori A . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 6 . 347–55 . 2001 . 11214970 . 10.1093/dnares/7.6.347 . etal. free .
• Chen H, Toyooka S, Gazdar AF, Hsieh JT . Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines . J. Biol. Chem. . 278 . 5 . 3121–30 . 2003 . 12446720 . 10.1074/jbc.M208230200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Zhang R, He X, Liu W . AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 . J. Clin. Invest. . 111 . 12 . 1933–43 . 2003 . 12813029 . 10.1172/JCI17790 . 161425 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• von Bergh AR, Wijers PM, Groot AJ . Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia . Genes Chromosomes Cancer . 39 . 4 . 324–34 . 2004 . 14978793 . 10.1002/gcc.20004 . 25835516 . etal.
• Dote H, Toyooka S, Tsukuda K . Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer . Clin. Cancer Res. . 10 . 6 . 2082–9 . 2004 . 15041729 . 10.1158/1078-0432.CCR-03-0236 . etal. free .
• Humphray SJ, Oliver K, Hunt AR . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . etal. 2004Natur.429..369H .
• Zhang H, Zhang R, Luo Y . AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation . J. Biol. Chem. . 279 . 43 . 44955–65 . 2004 . 15310755 . 10.1074/jbc.M407617200 . etal. free .
• Yano M, Toyooka S, Tsukuda K . Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers . Int. J. Cancer . 113 . 1 . 59–66 . 2004 . 15386433 . 10.1002/ijc.20531 . 24207780 . etal. free .
• Chen H, Tu SW, Hsieh JT . Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer . J. Biol. Chem. . 280 . 23 . 22437–44 . 2005 . 15817459 . 10.1074/jbc.M501379200 . free .
• Kunze E, Von Bonin F, Werner C . Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements . Int. J. Mol. Med. . 17 . 1 . 3–13 . 2006 . 16328005 . 10.3892/ijmm.17.1.3. etal. free .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.

Notes and References

1. Chen H, Pong RC, Wang Z, Hsieh JT . Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization . Genomics . 79 . 4 . 573–81 . April 2002 . 11944990 . 10.1006/geno.2002.6739 .
2. Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT . The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 . J Biol Chem . 277 . 15 . 12622–31 . April 2002 . 11812785 . 10.1074/jbc.M110568200 . free .
3. Web site: Entrez Gene: DAB2IP DAB2 interacting protein.
4. Wang . Zhi . Tseng Ching-Ping . Pong Rey-Chen . Chen Hong . McConnell John D . Navone Nora . Hsieh Jer-Tsong . April 2002 . The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 . J. Biol. Chem. . 277 . 15 . 12622–31 . 0021-9258. 11812785 . 10.1074/jbc.M110568200 . free .