D75-4590 Explained

D75-4590 is an antifungal pyridobenzimidazole derivative that inhibits β-glucan synthesis. D11-2040 and D21-6076 are antifungal derivatives of D75-4590.[1] [2]

Notes and References

  1. Kitamura . Akihiro . Someya . Kazuhiko . Hata . Masato . Nakajima . Ryohei . Takemura . Makoto . 2008 . Discovery of a Small-Molecule Inhibitor of β-1,6-Glucan Synthesis . Antimicrobial Agents and Chemotherapy . 53 . 2 . 670–7 . 2630612 . 19015325 . 10.1128/AAC.00844-08.
  2. Kitamura . Akihiro . Someya . Kazuhiko . Okumura . Ryo . Hata . Masato . Takeshita . Hiroshi . Nakajima . Ryohei . 2010 . In Vitro Antifungal Activities of D11-2040, a β-1,6-Glucan Inhibitor, with or without Currently Available Antifungal Drugs . Biological & Pharmaceutical Bulletin . 33 . 2 . 192–7 . 20118539 . 10.1248/bpb.33.192. free .

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