Delta24(241)-sterol reductase explained

delta24(24-1) sterol reductase
Ec Number:	1.3.1.71
Go Code:	0000246

In enzymology, a Delta24(241)-sterol reductase is an enzyme that catalyzes the chemical reaction

ergosterol + NADP⁺

\rightleftharpoons ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H⁺

Thus, the two substrates of this enzyme are ergosterol and NADP⁺, whereas its 3 products are ergosta-5,7,22,24(241)-tetraen-3beta-ol, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ergosterol:NADP+ Delta24(241)-oxidoreductase. Other names in common use include sterol Delta24(28)-methylene reductase, and sterol Delta24(28)-reductase. This enzyme participates in biosynthesis of steroids.

References

• Neal WD, Parks LW . 1977 . Sterol 24(28) methylene reductase in Saccharomyces cerevisiae . J. Bacteriol. . 129 . 1375 - 8 . 14922 . 3 . 235112 .
• Zweytick D, Hrastnik C, Kohlwein SD, Daum G . 2000 . Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae . FEBS Lett. . 470 . 83 - 7 . 10722850 . 10.1016/S0014-5793(00)01290-4 . 1 . free .