Xylulose Explained

Xylulose is a ketopentose, a monosaccharide containing five carbon atoms, and including a ketone functional group. It has the chemical formula . In nature, it occurs in both the L- and D-enantiomers.[1] 1-Deoxyxylulose is a precursor to terpenes via the DOXP pathway.[2]

Pathology

L-Xylulose accumulates in the urine in patients with pentosuria, due to a deficiency in L-xylulose reductase. Since L-xylulose is a reducing sugar like D-glucose, pentosuria patients have been wrongly diagnosed in the past to be diabetic.

Notes and References

  1. 10.1016/S0922-338X(98)80026-3. Microbial conversion of d-xylose to xylitol. 1998. Winkelhausen. Eleonora. Kuzmanova. Slobodanka. Journal of Fermentation and Bioengineering. 86. 1–14.
  2. 10.1042/BST0330785. Isoprenoid biosynthetic pathways as anti-infective drug targets. 2005. Rohdich. F.. Bacher. A.. Eisenreich. W.. Biochemical Society Transactions. 33. 4. 785–791. 16042599.