D-threo-aldose 1-dehydrogenase explained

D-threo-aldose 1-dehydrogenase
Ec Number:	1.1.1.122
Cas Number:	9082-70-6
Go Code:	0047834

In enzymology, a D-threo-aldose 1-dehydrogenase is an enzyme that catalyzes the chemical reaction

a D-threo-aldose + NAD⁺

\rightleftharpoons a D-threo-aldono-1,5-lactone + NADH + H⁺

Thus, the two substrates of this enzyme are D-threo-aldose and NAD⁺, whereas its 3 products are D-threo-aldono-1,5-lactone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-threo-aldose:NAD⁺ 1-oxidoreductase. Other names in common use include L-fucose dehydrogenase, (2S,3R)-aldose dehydrogenase, dehydrogenase, L-fucose, and L-fucose (D-arabinose) dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.

References

• Sasajima KI, Sinskey AJ . 1979 . Oxidation of L-glucose by a Pseudomonad . Biochim. Biophys. Acta . 571 . 120 - 6 . 40609 . 1 . 10.1016/0005-2744(79)90232-8 .
• Schachter H, Sarney J, McGuire EJ, Roseman S . 1969 . Isolation of diphosphopyridine nucleotide-dependent L-fucose dehydrogenase from pork liver . J. Biol. Chem. . 244 . 4785 - 92 . 4309152 . 17 .