D-sedoheptulose 7-phosphate isomerase explained

D-sedoheptulose 7-phosphate isomerase
Ec Number:5.3.1.28

D-sedoheptulose 7-phosphate isomerase (sedoheptulose-7-phosphate isomerase, phosphoheptose isomerase, gmhA (gene), lpcA (gene)) is an enzyme with systematic name D-glycero-D-manno-heptose 7-phosphate aldose-ketose-isomerase.[1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

D-sedoheptulose 7-phosphate

\rightleftharpoons

D-glycero-D-manno-heptose 7-phosphate

In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose.

Notes and References

  1. Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P . Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli . Journal of Bacteriology . 184 . 2 . 363–9 . January 2002 . 11751812 . 139585 . 10.1128/jb.184.2.363-369.2002 .
  2. Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P . Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose . The Journal of Biological Chemistry . 276 . 24 . 20935–44 . June 2001 . 11279237 . 10.1074/jbc.m100378200 . free .
  3. Valvano MA, Messner P, Kosma P . Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides . Microbiology . 148 . Pt 7 . 1979–89 . July 2002 . 12101286 . 10.1099/00221287-148-7-1979 . free .
  4. Kim MS, Shin DH . A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei . Acta Crystallographica Section F . 65 . Pt 11 . 1110–2 . November 2009 . 19923728 . 2777036 . 10.1107/s174430910903259x .
  5. Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS . Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants . The Journal of Biological Chemistry . 283 . 5 . 2835–45 . February 2008 . 18056714 . 10.1074/jbc.m706163200 . free .

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