D-inositol-3-phosphate glycosyltransferase explained

D-inositol-3-phosphate glycosyltransferase
Ec Number:2.4.1.250

D-inositol-3-phosphate glycosyltransferase (mycothiol glycosyltransferases, MshA) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase.[1] [2] [3] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

\rightleftharpoons

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

This enzyme catalyses the first dedicated reaction in the biosynthesis of mycothiol.

Notes and References

  1. Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y . The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA) . Journal of Bacteriology . 185 . 11 . 3476–9 . June 2003 . 12754249 . 155378 . 10.1128/JB.185.11.3476-3479.2003 .
  2. Newton GL, Ta P, Bzymek KP, Fahey RC . Biochemistry of the initial steps of mycothiol biosynthesis . The Journal of Biological Chemistry . 281 . 45 . 33910–20 . November 2006 . 16940050 . 10.1074/jbc.M604724200 . free .
  3. Vetting MW, Frantom PA, Blanchard JS . Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis . The Journal of Biological Chemistry . 283 . 23 . 15834–44 . June 2008 . 18390549 . 2414306 . 10.1074/jbc.M801017200 . free .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "D-inositol-3-phosphate glycosyltransferase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.