D-arabinose 1-dehydrogenase (NAD(P)+) explained

D-arabinose 1-dehydrogenase [NAD(P)<sup>+</sup>]
Ec Number:	1.1.1.117
Cas Number:	37250-48-9
Go Code:	0045290

In enzymology, a D-arabinose 1-dehydrogenase [NAD(P)⁺] is an enzyme that catalyzes the chemical reaction

D-arabinose + NAD(P)⁺

\rightleftharpoons D-arabinono-1,4-lactone + NAD(P)H + H⁺

The 3 substrates of this enzyme are D-arabinose, NAD⁺, and NADP⁺, whereas its 4 products are D-arabinono-1,4-lactone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-arabinose:NAD(P)⁺ 1-oxidoreductase. This enzyme is also called D-arabinose 1-dehydrogenase [NAD(P)⁺].

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Cline AL, Hu AS . 1965 . The isolation of three sugar dehydrogenases from a pseudomonad . J. Biol. Chem. . 240 . 4488 - 92 . 5845847 . 11 . 10.1016/S0021-9258(18)97087-0 . free .
• Cline AL, Hu AS . 1965 . Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad . J. Biol. Chem. . 240 . 4493 - 7 . 5845848 . 11 . 10.1016/S0021-9258(18)97088-2 . free .
• Cline AL, Hu AS . 1965 . Some physical properties of three sugar dehydrogenases from a pseudomonad . J. Biol. Chem. . 240 . 4498 - 502 . 5845849 . 11 . 10.1016/S0021-9258(18)97089-4 . free .