D-arabinitol dehydrogenase (NADP+) explained

D-arabinitol dehydrogenase (NADP^+)
Ec Number:	1.1.1.287

D-arabinitol dehydrogenase (NADP⁺) (NADP⁺-dependent D-arabitol dehydrogenase, ARD1p, D-arabitol dehydrogenase 1) is an enzyme with systematic name D-arabinitol:NADP⁺ oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

(1) D-arabinitol + NADP⁺

\rightleftharpoons D-xylulose + NADPH + H⁺

(2) D-arabinitol + NADP⁺

\rightleftharpoons D-ribulose + NADPH + H⁺

The enzyme present in the fungus Uromyces fabae can make use D-arabinitol and D-mannitol in the forward direction, and D-xylulose, D-ribulose and D-fructose in the reverse direction.

Notes and References

1. Link T, Lohaus G, Heiser I, Mendgen K, Hahn M, Voegele RT . Characterization of a novel NADP(+)-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae . The Biochemical Journal . 389 . Pt 2 . 289–95 . July 2005 . 15796718 . 1175105 . 10.1042/BJ20050301 .