D-arabinitol 2-dehydrogenase explained

D-arabinitol 2-dehydrogenase
Ec Number:	1.1.1.250
Cas Number:	336883-93-3
Go Code:	0047038

In enzymology, a D-arabinitol 2-dehydrogenase is an enzyme that catalyzes the chemical reaction

D-arabinitol + NAD⁺ ⇌ D-ribulose + NADH + H⁺

Thus, the two substrates of this enzyme are D-arabinitol and NAD⁺, whereas its 3 products are D-ribulose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-arabinitol:NAD⁺ 2-oxidoreductase (D-ribulose-forming). This enzyme is also called D-arabinitol 2-dehydrogenase (ribulose-forming).

References

• Wong B, Murray JS, Castellanos M, Croen KD . 1993 . D-arabitol metabolism in Candida albicans: studies of the biosynthetic pathway and the gene that encodes NAD-dependent D-arabitol dehydrogenase . J. Bacteriol. . 175 . 6314 - 20 . 8407803 . 19 . 10.1128/jb.175.19.6314-6320.1993 . 206728 .
• Quong MW, Miyada CG, Switchenko AC, Goodman TC . 1993 . Identification, purification, and characterization of a D-arabinitol-specific dehydrogenase from Candida tropicalis . Biochem. Biophys. Res. Commun. . 196 . 1323 - 9 . 8250887 . 10.1006/bbrc.1993.2397 . 3 .