D-alanine—poly(phosphoribitol) ligase explained
| D-Alanine—poly(phosphoribitol) ligase |
| Ec Number: | 6.1.1.13 |
| Cas Number: | 9023-65-8 |
| Go Code: | 0047473 |
In enzymology, a D-alanine—poly(phosphoribitol) ligase is an enzyme that catalyzes the chemical reaction
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
The 3 substrates of this enzyme are ATP, D-alanine, and poly(ribitol phosphate), whereas its 3 products are AMP, diphosphate, and O-D-alanyl-poly(ribitol phosphate).
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is D-alanine:poly(phosphoribitol) ligase (AMP-forming). Other names in common use include D-alanyl-poly(phosphoribitol) synthetase, D-alanine: membrane acceptor ligase, D-alanine-D-alanyl carrier protein ligase, D-alanine-membrane acceptor ligase, and D-alanine-activating enzyme. This enzyme participates in d-alanine metabolism.
References
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- ((Reusch VM Jr)), Neuhaus FC . 1971 . D-Alanine: membrane acceptor ligase from Lactobacillus casei . J. Biol. Chem. . 246 . 6136 - 43 . 4399593 . 20 .
- Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W . 1995 . Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation . J. Biol. Chem. . 270 . 15598 - 606 . 7797557 . 26 . 10.1074/jbc.270.26.15598. free .
- Heaton MP, Neuhaus FC . 1994 . Role of the D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid . J. Bacteriol. . 176 . 681 - 90 . 8300523 . 3 . 205105 .
- Debabov DV, Heaton MP, Zhang Q, Stewart KD, Lambalot RH, Neuhaus FC . 1996 . The D-Alanyl carrier protein in Lactobacillus casei: cloning, sequencing, and expression of dltC . J. Bacteriol. . 178 . 3869 - 76 . 8682792 . 13 . 232648 .
