D-161 Explained

D-161[1] is a chemical known in research circles as a triple reuptake inhibitor. Although this compound has lent support to the inclusion of dopamine in the monoamine hypothesis of depression, D-161 has not been tested in clinical trials.

Notes and References

  1. Dutta AK, Ghosh B, Biswas S, Reith ME . D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action . European Journal of Pharmacology . 589 . 1–3 . 73–9 . July 2008 . 18561912 . 10.1016/j.ejphar.2008.05.008 .

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