Déborah Bourc'his Explained

Déborah Bourc'his is a French researcher in Epigenetics. She is currently a team leader at the Curie Institute (Paris). Her research has been awarded the prize Liliane-Bettencourt for life sciences.

Education and academic appointments

In 1996.,[1] she joins the laboratory of Evani Viegas-Pequignot to do a PhD in Genetics in at the Necker–Enfants Malades Hospital.[2] There, she identifies methylation mutations on DNMT3B.

In 2000,[1] she moves to the laboratory of Timothy Bestor at the Columbia University to start her postdoctoral studies.

In 2009, after being recruited at the french biomedical research institute Inserm, she is invited by Edith Heard to start her own research team at the Curie Institute (Paris).[3]

Research

During her postdoctoral studies, she shows that germline cells require a specific stimulation to acquire DNA methylation, via the cofactor 3 DNMT3L.[4]

Déborah Bourc'his runs a research team studying epigenetic decisions and reproduction in the department 'Genetics and Developmental biology' of the Curie Institute.[5] Her research focuses on understanding the regulation of epigenetic information within the peri-conception window, from Gametogenesis to early embryonic development.[6] She has published several key publications in the field.[7] [8] Her work has been awarded several prestigious prizes.

Awards

Notes and References

  1. Web site: Déborah Bourc'his : Pasionaria de l'épigénétique. Inserm - La science pour la santé. fr. 2020-05-07.
  2. Identification du gene et de l'origine embryonnaire du defaut de methylation de l'aon des patienst icf. Paris 7. 2000-01-01. thesis. Déborah. Bourc'his.
  3. Web site: Epigenetic Decisions and Reproduction. Centre de recherche de l'Institut Curie. en-US. 2020-05-07.
  4. Bourc'his. Déborah. Bestor. Timothy H.. September 2004. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature. en. 431. 7004. 96–99. 10.1038/nature02886. 15318244 . 4422237 . 1476-4687.
  5. Web site: U934/UMR3215 - Genetics and Developmental Biology. Centre de recherche de l'Institut Curie. en-US. 2020-05-07.
  6. News: 2018-10-17. Le mystérieux rôle de l'épigénétique. fr. Le Monde.fr. 2020-05-07.
  7. Greenberg. Maxim V. C.. Glaser. Juliane. Borsos. Máté. Marjou. Fatima El. Walter. Marius. Teissandier. Aurélie. Bourc'his. Déborah. January 2017. Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nature Genetics. en. 49. 1. 110–118. 10.1038/ng.3718. 27841881 . 4164945 . 1546-1718.
  8. Barau. Joan. Teissandier. Aurélie. Zamudio. Natasha. Roy. Stéphanie. Nalesso. Valérie. Hérault. Yann. Guillou. Florian. Bourc’his. Déborah. 2016-11-18. The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science. en. 354. 6314. 909–912. 10.1126/science.aah5143. 0036-8075. 27856912. 30907442 .
  9. Web site: Les lauréats 2017 des prix scientifiques de la Fondation Bettencourt Schueller. 2017-11-10. Fondation Bettencourt Schueller. fr. 2020-05-07.
  10. Web site: Cercle FSER. FSER. Cercle. Cercle FSER. fr-FR. 2020-05-07.

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