Cytoskeleton regulator RNA explained

Cytoskeleton regulator RNA is a long non-coding RNA that in humans is encoded by the CYTOR gene.

CYTOR plays a role in breast cancer. It regulates genes involved in the EGFR/mammalian target of rapamycin pathway and is required for cell proliferation, cell migration, and cytoskeleton organization.^{[1] [2]}

Further reading

• Van Grembergen O, Bizet M, de Bony EJ, Calonne E, Putmans P, Brohée S, Olsen C, Guo M, Bontempi G, Sotiriou C, Defrance M, Fuks F . Portraying breast cancers with long noncoding RNAs. . Sci Adv . 2 . 9 . 2016 . 10.1126/sciadv.1600220 . 27617288. 5010371 . e1600220. 2016SciA....2E0220V .
• Pang Q, Ge J, Shao Y, Sun W, Song H, Xia T, Xiao B, Guo J . Increased expression of long intergenic non-coding RNA LINC00152 in gastric cancer and its clinical significance . Tumour Biol. . 35 . 6 . 5441–7 . 2014 . 24523021 . 10.1007/s13277-014-1709-3 . 1025668 .
• Tani H, Onuma Y, Ito Y, Torimura M . Long non-coding RNAs as surrogate indicators for chemical stress responses in human-induced pluripotent stem cells . PLOS ONE . 9 . 8 . e106282 . 2014 . 25171338 . 4149554 . 10.1371/journal.pone.0106282 . 2014PLoSO...9j6282T . free .
• Zhao J, Liu Y, Zhang W, Zhou Z, Wu J, Cui P, Zhang Y, Huang G . Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer . Cell Cycle . 14 . 19 . 3112–23 . 2015 . 26237576 . 4825539 . 10.1080/15384101.2015.1078034 .
• Li J, Wang X, Tang J, Jiang R, Zhang W, Ji J, Sun B . HULC and Linc00152 Act as Novel Biomarkers in Predicting Diagnosis of Hepatocellular Carcinoma . Cell. Physiol. Biochem. . 37 . 2 . 687–96 . 2015 . 26356260 . 10.1159/000430387 . free .
• Zhou J, Zhi X, Wang L, Wang W, Li Z, Tang J, Wang J, Zhang Q, Xu Z . Linc00152 promotes proliferation in gastric cancer through the EGFR-dependent pathway . J. Exp. Clin. Cancer Res. . 34 . 135 . 2015 . 26538117 . 4632266 . 10.1186/s13046-015-0250-6 . free .
• Ji J, Tang J, Deng L, Xie Y, Jiang R, Li G, Sun B . LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway . Oncotarget . 6 . 40 . 42813–24 . 2015 . 26540343 . 4767473 . 10.18632/oncotarget.5970 .
• Chen WM, Huang MD, Sun DP, Kong R, Xu TP, Xia R, Zhang EB, Shu YQ . Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer . Oncotarget . 7 . 9 . 9773–87 . 2016 . 26799422 . 4891083 . 10.18632/oncotarget.6949 .
• Yue B, Cai D, Liu C, Fang C, Yan D . Linc00152 Functions as a Competing Endogenous RNA to Confer Oxaliplatin Resistance and Holds Prognostic Values in Colon Cancer . Mol. Ther. . 24 . 12 . 2064–2077 . 2016 . 27633443 . 10.1038/mt.2016.180 . 5167786.
• Hu HB, Jie HY, Zheng XX . Three Circulating LncRNA Predict Early Progress of Esophageal Squamous Cell Carcinoma . Cell. Physiol. Biochem. . 40 . 1–2 . 117–125 . 2016 . 27855375 . 10.1159/000452529 . free .

Notes and References

1. Van Grembergen. Olivier. Portraying breast cancer with long non coding RNA. Science Advances. 2016. 10.1126/sciadv.1600220. 5010371. 27617288. 2. 9. e1600220. 2016SciA....2E0220V .
2. Web site: Entrez Gene: Cytoskeleton regulator RNA. 2017-09-04. 2016-10-01. https://web.archive.org/web/20161001203403/http://www.ncbi.nlm.nih.gov/gene/112597. live.