Cytokine dependent hematopoietic cell linker explained

Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene.^[1]

Function

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).

Further reading

• Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O . Screening for replication of genome-wide SNP associations in sporadic ALS . Eur. J. Hum. Genet. . 17 . 2 . 213–8 . 2009 . 18987618 . 2986065 . 10.1038/ejhg.2008.194 .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Jin TB, Ren Y, Shi X, Jiri M, He N, Feng T, Yuan D, Kang L . Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets . Rheumatol. Int. . 35 . 7 . 1141–7 . 2015 . 25591661 . 10.1007/s00296-015-3215-3 . 23426576 .

Notes and References

1. Web site: Entrez Gene: Cytokine dependent hematopoietic cell linker. 2017-09-06.