Cytokine-like protein 1 explained

Cytokine-like protein 1 (also protein C17) is a protein that in humans is encoded by the CYTL1 gene.^[1]

Function

Protein C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 surface marker. Functionally, C17 was identified as a secretory protein expressed in CD34+ haemopoietic cells.^[2] CYTL1 seems to regulate chondrogenesis and is required for the maintenance of cartilage homeostasis and might, additionally, work as a regulatory factor in embryo implantation in the stage of early pregnancy.^[3]

This family of proteins, C17, is found in vertebrates. Proteins have two conserved sequence motifs: PPTCYSR and DDC.

Further reading

• Deng X, Zhao HS, Peng Z, Deng WW, Li N, Guo S, Shi TP . [Study on the mechanism of C17orf62 induced cell death] . Beijing da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences . 43 . 2 . 168–72 . April 2011 . 21503106 .
• Tomczak A, Pisabarro MT . Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model . Proteins . 79 . 4 . 1277–92 . April 2011 . 21322034 . 10.1002/prot.22963 . 24312749 .
• Chao C, Joyce-Shaikh B, Grein J, Moshrefi M, Raoufi F, Laface DM, McClanahan TK, Bourne PA, Pierce RH, Gorman DM, Pflanz S . C17 prevents inflammatory arthritis and associated joint destruction in mice . PLOS ONE . 6 . 7 . e22256 . 2011 . 21799806 . 3143151 . 10.1371/journal.pone.0022256 . 2011PLoSO...622256C . free .
• Chen XD, Xiong DH, Yang TL, Pei YF, Guo YF, Li J, Yang F, Pan F, Tan LJ, Yan H, Liu XG, Lei SF, Li X, Ning LL, Zhu XZ, Levy S, Kranzler HR, Farrer LA, Gelernter J, Recker RR, Deng HW . ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior . Chinese Medical Journal . 125 . 6 . 1127–34 . March 2012 . 22613542 . 4174677 .
• Kwon YJ, Lee SJ, Koh JS, Kim SH, Lee HW, Kang MC, Bae JB, Kim YJ, Park JH . Genome-wide analysis of DNA methylation and the gene expression change in lung cancer . Journal of Thoracic Oncology . 7 . 1 . 20–33 . January 2012 . 22011669 . 10.1097/JTO.0b013e3182307f62 . free .

Notes and References

1. Web site: Entrez Gene: Cytokine-like 1 .
2. Liu X, Rapp N, Deans R, Cheng L . Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells . Genomics . 65 . 3 . 283–92 . May 2000 . 10857752 . 10.1006/geno.2000.6170 .
3. Ai Z, Jing W, Fang L . Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation . PLOS ONE . 11 . 1 . e0147424 . 2016 . 26800213 . 4723121 . 10.1371/journal.pone.0147424 . 2016PLoSO..1147424A . free .