Cytochrome P450 eryF explained

Cytochrome P450 eryF
Organism:	Saccharopolyspora erythraea
Taxid:	1836
Symbol:	eryF
Altsymbols:	CYP107A1
Uniprot:	Q00441
Ecnumber:	1.14.15.35

6-deoxyerythronolide B hydroxylase is an Actinomycetota Cytochrome P450 enzyme originally from Saccharopolyspora erythraea, catalyzes the 6S-hydroxylate of 6-deoxyerythronolide B (6-DEB) to erythronolide B (EB) which is the first step of biosynthesis of the macrolide antibiotic erythromycin.^{[1] [2]} This bacterial enzyme belongs to CYP family CYP107, with the CYP Symbol CYP107A1.^{[3] [4]}

Notes and References

1. Weber JM, Leung JO, Swanson SJ, Idler KB, McAlpine JB . An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea . Science . 252 . 5002 . 114–7 . April 1991 . 2011746 . 10.1126/science.2011746 . 1991Sci...252..114W .
2. Andersen JF, Hutchinson CR . Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase . Journal of Bacteriology . 174 . 3 . 725–35 . February 1992 . 1732208 . 10.1128/jb.174.3.725-735.1992 . 206148 .
3. Cupp-Vickery JR, Poulos TL . Structure of cytochrome P450eryF involved in erythromycin biosynthesis . Nature Structural Biology . 2 . 2 . 144–53 . February 1995 . 7749919 . 10.1038/nsb0295-144 . 22536232 .
4. Harris DL . Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450eryF . Journal of Inorganic Biochemistry . 91 . 4 . 568–85 . September 2002 . 12237223 . 10.1016/s0162-0134(02)00477-4 .