Cytochrome-c3 hydrogenase explained
| cytochrome-c3 hydrogenase |
| Ec Number: | 1.12.2.1 |
| Cas Number: | 9027-05-8 |
| Go Code: | 0047806 |
In enzymology, a cytochrome-c3 hydrogenase is an enzyme that catalyzes the chemical reaction
2 H2 + ferricytochrome c3
4 H
+ + ferrocytochrome c
3Thus, the two substrates of this enzyme are H2 and ferricytochrome c3, whereas its two products are H+ and ferrocytochrome c3.
This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with a cytochrome as acceptor. The systematic name of this enzyme class is hydrogen:ferricytochrome-c3 oxidoreductase. Other names in common use include H2:ferricytochrome c3 oxidoreductase, cytochrome c3 reductase, cytochrome hydrogenase, and hydrogenase [ambiguous]. It has 3 cofactors: iron, Nickel, and Iron-sulfur.
Structural studies
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,,,, and .
References
- DerVartanian DV . Le Gall J . 1974 . A monomolecular electron transfer chain: structure and function of cytochrome c3 . Biochim. Biophys. Acta . 346 . 79 - 99 . 4364940 . 1 . 10.1016/0304-4173(74)90012-3.
- Higuchi Y, Yasuoka N, Kakudo M, Katsube Y, Yagi T, Inokuchi H . 1987 . Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F . J. Biol. Chem. . 262 . 2823 - 5 . 3546297 . 6 .
- Rilkis E . Rittenberg D . 1961 . Some observations on the enzyme, hydrogenase . J. Biol. Chem. . 236 . 2526 - 2529 . 13741672.
- Sadana JC . Morey AV . 1961 . Purification and properties of the hydrogenase of Desulfovibrio desulfuricans . Biochim. Biophys. Acta . 50 . 153 - 163 . 10.1016/0006-3002(61)91072-1 . 13745271.
- Fontecilla-Camps JC . 1995 . Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas . Nature . 373 . 580 - 7 . 7854413 . 10.1038/373580a0 . Charon . MH . Piras . C . Hatchikian . EC . Frey . M . Fontecilla-Camps . JC . 6515 . 1995Natur.373..580V . 4335445 .
- Fontecilla-Camps JC . 1999 . The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center . Structure . 7 . 557 - 66 . 10378275 . 10.1016/S0969-2126(99)80072-0 . Vernede . X . Hatchikian . EC . Volbeda . A . Frey . M . Fontecilla-Camps . JC . 5 . free .
