Hexaminolevulinate Explained

Tradename:Cysview, Hexvix
Dailymedid:Hexaminolevulinate
Atc Prefix:V04
Atc Suffix:CX06
Legal Au:S4
Legal Au Comment:[1]
Legal Ca:Rx-only
Legal Us:Rx-only
Legal Us Comment:[2]
Cas Number:140898-97-1
Pubchem:6433083
Drugbank:DB06261
Chemspiderid:4938272
Unii:G7H20TKI67
Kegg:D04436
Chebi:134892
Chembl:1201784

Hexaminolevulinate, sold under the brand name Cysview among others, is an imaging agent that lights up under blue light during a blue light cystoscopy. It is used to help detect non-muscle invasive bladder cancer (NMIBC), in particular papillary tumors and carcinoma in situ (CIS).

It made by Photocure ASA, a Norwegian pharmaceutical company.

Hexaminolevulinate is a structural analogue to 5-aminolevulinic acid (a precursor to the porphyrin ring of heme), and is internalized and processed into the photoactive protoporphyrin IX at a high rate by tumor cells. After exposure to 360-450 nm light, the porphyrin will fluoresce red.https://pubchem.ncbi.nlm.nih.gov/compound/Hexaminolevulinate#section=Metabolism-Metabolites

Notes and References

  1. Web site: Prescription medicines: registration of new chemical entities in Australia, 2016 . Therapeutic Goods Administration (TGA) . 21 June 2022 . 10 April 2023.
  2. Web site: Cysview- hexaminolevulinate hydrochloride kit . DailyMed . 15 November 2022 . 10 April 2023.