Cyprodime Explained
Cyprodime is an opioid antagonist from the morphinan family of drugs.
Cyprodime is a selective opioid antagonist which blocks the μ-opioid receptor,[1] but without affecting the δ-opioid or κ-opioid receptors. This makes it useful for scientific research as it allows the μ-opioid receptor to be selectively deactivated so that the actions of the δ and κ receptors can be studied separately, in contrast to better known opioid antagonists such as naloxone which block all three opioid receptor subtypes.[2]
See also
- Tianeptine, an atypical, selective MOR full-agonist licensed for major depression since 1989.
- Samidorphan, an opioid antagonist preferring the MOR, which is under development for major depression.
Notes and References
- Schmidhammer H, Burkard WP, Eggstein-Aeppli L, Smith CF . Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist . Journal of Medicinal Chemistry . 32 . 2 . 418–21 . February 1989 . 2536439 . 10.1021/jm00122a021 .
- Márki A, Monory K, Otvös F, Tóth G, Krassnig R, Schmidhammer H, Traynor JR, Roques BP, Maldonado R, Borsodi A . 6 . Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays . European Journal of Pharmacology . 383 . 2 . 209–14 . October 1999 . 10585536 . 10.1016/s0014-2999(99)00610-x .
