| Competition: | Cypriot First Division |
| Season: | 1945–46 |
| Prevseason: | 1944–45 |
| Nextseason: | 1946–47 |
The 1945–46 Cypriot First Division was the 9th season of the Cypriot top-level football league.
It was contested by 6 teams, and EPA Larnaca FC won the championship.