Cyprazepam Explained

Cyprazepam[1] is a drug which is a sedative-hypnotic benzodiazepine derivative.[2] [3] [4] [5] It has anxiolytic properties,[6] and presumably also has hypnotic, skeletal muscle relaxant, anticonvulsant and amnestic properties.

Synthesis

The lactam moiety in benzodiazepams is active towards nucleophiles and numerous analogues have been made by exploiting this fact.For example, heating demoxepam with N-cyclopropylmethylamine leads to amidine formation, the minor tranquilizer cyprazepam.

See also

Notes and References

  1. 2-Cycloalkylamino Derivatives of 1,4-Benzodiazipines . US . 3138586 . Wuest HM . Warner-Lambert Pharmaceutical Company . 23 June 1964 .
    Chem. Abstr., 61: 7,032f (1964).
  2. Oelschläger H, Martienssen D, Belal F . 22 September 2006 . Ring Contraction of 1,4-Benzodiazepines to 3,4-Dihydroquinazolines During Macro Scale Reduction (Example 5: Cyprazepam) . Archiv der Pharmazie . 325 . 8 . 503–507 . Wiley Interscience . 10.1002/ardp.19923250810 . 96638676 . https://archive.today/20130105101913/http://www3.interscience.wiley.com/journal/113348763/abstract . dead . 5 January 2013 . 0365-6233 .
  3. Matthews B, Victor S, Nigel, Swindell C . American Regent Inc. . DHA-pharmaceutical agent conjugates . EP . 1466628 . 13 October 2004 .
  4. Web site: Harmonized Tariff Schedule of the United States (2009) - Supplement 1 - PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE . United States International Trade Commission . USA . 2009 . 19 September 2009 . dead . https://web.archive.org/web/20090731024827/http://www.usitc.gov/publications/docs/tata/hts/bychapter/0910PHARMAPPX.pdf . 31 July 2009 .
  5. Schafer EW, Bowles WA, Hurlbut J . 32956594 . The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more species of wild and domestic birds . Archives of Environmental Contamination and Toxicology . 12 . 3 . 355–82 . May 1983 . 6882015 . 10.1007/BF01059413 . 1983ArECT..12..355S .
  6. Web site: World Health Organization . The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances . . USA . 2006 . 19 September 2009.

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