Cyclosporins Explained

The cyclosporins are a group of macrolides isolated from fungi and used as immunosuppresant drugs, for example after transplant surgery. They are nonribosomal peptide synthesized by cyclosporin synthetase.^[1]

• Cyclosporin A (ciclosporin)
• Cyclosporin B
• Cyclosporin C
• Cyclosporin D
• Cyclosporin E
• Cyclosporin F
• Cyclosporin G

References

1. Lawen A . Biosynthesis of cyclosporins and other natural peptidyl prolyl cis/trans isomerase inhibitors . Biochimica et Biophysica Acta (BBA) - General Subjects . 1850 . 10 . 2111–20 . October 2015 . 25497210 . 10.1016/j.bbagen.2014.12.009 .