Cyclopregnol Explained

Cyclopregnol (INN), also known as neurosterone, as well as 6β-hydroxy-3:5-cyclopregnan-20-one, is a synthetic pregnane steroid which was developed in the 1950s as a "psychotropic agent" for the treatment of mental disorders but was never marketed.^{[1] [2] [3] [4]} Although an initial small clinical study found effectiveness, a subsequent, larger and more rigorous study found that cyclopregnol was no more effective than placebo and was clearly inferior to chlorpromazine.^[5]

See also

• List of neurosteroids

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 646–.
2. Patel DK, Petrow V, Stuart-Webb IA . 133. 6β-Hydroxy-3 : 5-cyclopregnan-20-one and some related compounds. J. Chem. Soc.. 1957. 665–668. 0368-1769. 10.1039/JR9570000665.
3. Hardwick SW, Pearse JJ, Petrow V . 6 beta-Hydroxy-3:5-cyclopregnan-20-one in mental states . The Journal of Mental Science . 103 . 433 . 835–839 . October 1957 . 13481595 . 10.1192/bjp.103.433.835 .
4. Loranger AW . Treatment of acute mental disorders with an adrenal steroid . The British Journal of Psychiatry . 114 . 512 . 843–844 . July 1968 . 4874165 . 10.1192/bjp.114.512.843 . 45608631 .
5. Book: Pachter IJ, Rubin AA . Antipyschotic and Anti-anxiety Agents . Childress SJ D. Annual Reports in Medicinal Chemistry. https://books.google.com/books?id=rDUMWpvOgjkC&pg=PA3. 1969. Academic Press. 978-0-08-058348-8. 3–.