Cyclomaltodextrinase Explained

Cyclomaltodextrinase
Ec Number:	3.2.1.54
Cas Number:	37288-41-8
Go Code:	0047798

The enzyme cyclomaltodextrinase catalyzes the chemical reaction

cyclomaltodextrin + H₂O

\rightleftharpoons linear maltodextrin

It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is cyclomaltodextrin dextrin-hydrolase (decyclizing). Other names in common use include cycloheptaglucanase, cyclohexaglucanase, and cyclodextrinase. The enzyme participates in starch and sucrose metabolism and acarbose degradation.^{[1] [2]} The cyclomaltodextrinase is capable of degradation of acarbose to glucose and acarviosine-glucose.^[3]

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

Further reading

• DePinto JA, Campbell LL . Purification and properties of the cyclodextrinase of Bacillus macerans . Biochemistry . 7 . 1 . 121–125 . January 1968 . 4922856 . 10.1021/bi00841a016 .

Notes and References

1. Jang MU, Jeong CK, Kang HJ, Kim MJ, Lee MJ, Son BS, Kim TJ . 2016. Gene Cluster Analysis and Functional Characterization of Cyclomaltodextrinase from Listeria innocua . Microbiology and Biotechnology Letters. 44. 3. 363–369. 10.4014/mbl.1608.08008. 1598-642X.
2. Jang MU, Kang HJ, Jeong CK, Kang Y, Park JE, Kim TJ . Functional expression and enzymatic characterization of Lactobacillus plantarum cyclomaltodextrinase catalyzing novel acarbose hydrolysis . Journal of Microbiology . 56 . 2 . 113–118 . February 2018 . 29392561 . 10.1007/s12275-018-7551-3 .
3. Park KH . 2006. Function and Tertiary- and Quaternary-structure of Cyclodextrin-hydrolyzing Enzymes (CDase), a Group of Multisubstrate Specific Enzymes Belonging to the α-Amylase Family . Journal of Applied Glycoscience. 53. 1. 35–44. 10.5458/jag.53.35. free.