Cyclohexa-1,5-dienecarbonyl-CoA hydratase explained

cyclohexa-1,5-dienecarbonyl-CoA hydratase
Ec Number:	4.2.1.100
Go Code:	0018823

The enzyme cyclohexa-1,5-dienecarbonyl-CoA hydratase catalyzes the chemical reaction

6-hydroxycyclohex-1-enecarbonyl-CoA

\rightleftharpoons cyclohexa-1,5-dienecarbonyl-CoA + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming). Other names in common use include cyclohexa-1,5-diene-1-carbonyl-CoA hydratase, dienoyl-CoA hydratase, and cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect). This enzyme participates in benzoate degradation via CoA ligation.

References

• Laempe D, Eisenreich W, Bacher A, Fuchs G . 1998 . Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica . Eur. J. Biochem. . 255 . 618 - 27 . 9738901 . 10.1046/j.1432-1327.1998.2550618.x . 3 . free .
• Harwood CS, Gibson J . 1997 . Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes? . J. Bacteriol. . 179 . 301 - 9 . 8990279 . 2 . 178697 .
• Koch J, Eisenreich W, Bacher A, Fuchs G . 1993 . Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism . Eur. J. Biochem. . 211 . 649 - 61 . 8436125 . 10.1111/j.1432-1033.1993.tb17593.x . 3 . free .