Cyclic pyranopterin monophosphate synthase explained

Cyclic pyranopterin monophosphate synthase
Ec Number:	4.1.99.18

Cyclic pyranopterin monophosphate synthase (MOCS1A, MoaA, MoaC, molybdenum cofactor biosynthesis protein 1) is an enzyme with systematic name GTP 8,9-lyase (cyclic pyranopterin monophosphate-forming).^{[1] [2] [3] [4] [5] [6] [7]} This enzyme catalyses the following chemical reaction

GTP

\rightleftharpoons cyclic pyranopterin monophosphate + diphosphate

This enzyme catalyses an early step in the biosynthesis of molybdopterin.

Notes and References

1. Rieder C, Eisenreich W, O'Brien J, Richter G, Götze E, Boyle P, Blanchard S, Bacher A, Simon H . Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors . European Journal of Biochemistry . 255 . 1 . 24–36 . July 1998 . 9692897 . 10.1046/j.1432-1327.1998.2550024.x .
2. Wuebbens MM, Rajagopalan KV . Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies . The Journal of Biological Chemistry . 270 . 3 . 1082–7 . January 1995 . 7836363 . 10.1074/jbc.270.3.1082 . free .
3. Hänzelmann P, Hernández HL, Menzel C, García-Serres R, Huynh BH, Johnson MK, Mendel RR, Schindelin H . Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis . The Journal of Biological Chemistry . 279 . 33 . 34721–32 . August 2004 . 15180982 . 10.1074/jbc.M313398200 . free .
4. Hänzelmann P, Schindelin H . Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans . Proceedings of the National Academy of Sciences of the United States of America . 101 . 35 . 12870–5 . August 2004 . 15317939 . 516487 . 10.1073/pnas.0404624101 . free .
5. Sanishvili R, Beasley S, Skarina T, Glesne D, Joachimiak A, Edwards A, Savchenko A . The crystal structure of Escherichia coli MoaB suggests a probable role in molybdenum cofactor synthesis . The Journal of Biological Chemistry . 279 . 40 . 42139–46 . October 2004 . 15269205 . 3366512 . 10.1074/jbc.M407694200 . free .
6. Hänzelmann P, Schindelin H . Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism . Proceedings of the National Academy of Sciences of the United States of America . 103 . 18 . 6829–34 . May 2006 . 16632608 . 1458979 . 10.1073/pnas.0510711103 . free .
7. Lees NS, Hänzelmann P, Hernandez HL, Subramanian S, Schindelin H, Johnson MK, Hoffman BM . ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications . Journal of the American Chemical Society . 131 . 26 . 9184–5 . July 2009 . 19566093 . 2757093 . 10.1021/ja903978u .