Cyanoacetamide Explained

2-Cyanoacetamide is an organic compound. It is an acetic amide with a nitrile functional group.

Uses

Cyanoacetamide is used in spectrofluorimetric methods to determine the activity of antihistamine H1 receptor antagonistic drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride.[1]

Preparation

2-Cyanoacetamide is prepared from chloroacetic acid via Kolbe nitrile synthesis[2] followed by Fischer esterification and ester aminolysis.[3]

See also

Notes and References

  1. Ibrahim. F.. Sharaf El-Din. M. K.. Eid. M.. Wahba. M. E. K.. Spectrofluorimetric Determination Of Some H1 Receptor Antagonist Drugs In Pharmaceutical Formulations And Biological Fluids. International Journal of Pharmaceutical Sciences and Research. 2011. 21. 8. 2056–2072. 10.13040/IJPSR.0975-8232.2(8).2056-72. free.
  2. Inglis. J. K. H.. Ethyl Cyanoacetate. Organic Syntheses. 1928. 8. 74. 10.15227/orgsyn.008.0074.
  3. Corson. B. B.. Scott. R. W.. Vose. C. E.. Cyanoacetamide. Organic Syntheses. 1941. 1. 179. 10.15227/orgsyn.009.0036.

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