GJC1 explained

Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene.^[1]

Function

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.^[2]

Further reading

• Book: Andrew L Harris . Darren Locke . Connexins, A Guide . Springer . 2009 . New York . 574 . 978-1-934115-46-6.
• Kilarski WM, Dupont E, Coppen S . Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term. . Eur. J. Cell Biol. . 75 . 1 . 1–8 . 1998 . 9523149 . 10.1016/S0171-9335(98)80040-X. etal.
• Vozzi C, Dupont E, Coppen SR . Chamber-related differences in connexin expression in the human heart. . J. Mol. Cell. Cardiol. . 31 . 5 . 991–1003 . 1999 . 10336839 . 10.1006/jmcc.1999.0937 . etal.
• Chanson M, Scerri I, Suter S . Defective regulation of gap junctional coupling in cystic fibrosis pancreatic duct cells. . J. Clin. Invest. . 103 . 12 . 1677–84 . 1999 . 10377174 . 10.1172/JCI5645 . 408381 .
• Kausalya PJ, Reichert M, Hunziker W . Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells. . FEBS Lett. . 505 . 1 . 92–6 . 2001 . 11557048 . 10.1016/S0014-5793(01)02786-7 . 13489358 .
• Laing JG, Manley-Markowski RN, Koval M . Connexin45 interacts with zonula occludens-1 in osteoblastic cells. . Cell Commun. Adhes. . 8 . 4–6 . 209–12 . 2003 . 12064590 . 10.3109/15419060109080725 . 23039209 . etal. free .
• Kaba RA, Coppen SR, Dupont E . Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts. . Cell Commun. Adhes. . 8 . 4–6 . 339–43 . 2003 . 12064615 . 10.3109/15419060109080750 . 23388741 . etal. free .
• Xiang Q, Fan SQ, Li J . [Expression of connexin43 and connexin45 in nasopharyngeal carcinoma] . AI Zheng . 21 . 6 . 593–6 . 2003 . 12452056 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Tsai MY, Lan KC, Huang KE . Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles. . Fertil. Steril. . 80 . 6 . 1437–43 . 2004 . 14667880 . 10.1016/j.fertnstert.2003.05.015 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Valiunas V, Doronin S, Valiuniene L . Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. . J. Physiol. . 555 . Pt 3 . 617–26 . 2004 . 14766937 . 10.1113/jphysiol.2003.058719 . 1664864 . etal.
• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Laing JG, Koval M, Steinberg TH . Association with ZO-1 correlates with plasma membrane partitioning in truncated connexin45 mutants. . J. Membr. Biol. . 207 . 1 . 45–53 . 2007 . 16463142 . 10.1007/s00232-005-0803-2 . 20032015 .
• Rackauskas M, Kreuzberg MM, Pranevicius M . Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45. . Biophys. J. . 92 . 6 . 1952–65 . 2007 . 17189315 . 10.1529/biophysj.106.099358 . 1861779 . 2007BpJ....92.1952R . etal.
• Kotsias BA, Salim M, Peracchia LL, Peracchia C . Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes. . J. Membr. Biol. . 214 . 1 . 1–8 . 2007 . 17546509 . 10.1007/s00232-006-0064-8 . 7095255 .

Notes and References

1. Kanter HL, Saffitz JE, Beyer EC . Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45 . J Mol Cell Cardiol . 26 . 7 . 861–8 . Dec 1994 . 7966354 . 10.1006/jmcc.1994.1103 .
2. Web site: Entrez Gene: GJA7 gap junction protein, alpha 7, 45kDa.