Cumyl alcohol explained

Cumyl alcohol, also called 4-isopropylbenzyl alcohol, is a liquid, hydroxy functional, aromatic organic chemical with formula C10H14O. It has the CAS Registry Number of 536-60-7 and the IUPAC name of (4-propan-2-ylphenyl)methanol.[1] [2] It is REACH registered with the EC number of 208-640-4.[3]

Uses

The most common use is as a food additive to add flavor.[4] [5] The material also has insect repellent properties.[6]

Manufacture

Hydrogenation of cuminal can produce cumyl alcohol.[7]

Other

Cumyl alcohol is an undesired side reaction product when LDPE is crosslinked.[8] LDPE is used as a plastic electric insulator for electrical power cables.[9] The cumyl alcohol reduces the insulating properties.[10] [11]

Alternative names

Main sources of information.[12] [13]

Toxicology

The toxicity of the material has been studied and is reasonably well understood.[16] [17] [18]

Notes and References

  1. Web site: PubChem . 4-Isopropylbenzyl alcohol . 2023-03-28 . pubchem.ncbi.nlm.nih.gov . en.
  2. Web site: 4-isopropylbenzyl alcohol . 2023-03-28 . www.wikidata.org . en.
  3. Web site: Substance Information - ECHA . 2023-03-29 . echa.europa.eu . en-GB.
  4. Web site: P-ISOPROPYLBENZYL ALCOHOL FEMA . 2023-03-29 . www.femaflavor.org.
  5. Web site: Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 EFSA . 2023-03-29 . www.efsa.europa.eu . 9 January 2006 . en.
  6. Web site: 4-Isopropylbenzyl alcohol CAS 536-60-7 SCBT - Santa Cruz Biotechnology . 2023-03-29 . www.scbt.com.
  7. Cooke . R. G. . Gillespie . D. T. . Macbeth . A. Killen . 1938-01-01 . 338. Cumyl alcohol . Journal of the Chemical Society (Resumed) . en . 1825–1826 . 10.1039/JR9380001825 . 0368-1769.
  8. Book: Hirai . N. . Maeno . Y. . Tanaka . T. . Ohki . Y. . Okashita . M. . Maeno . T. . 2003 Annual Report Conference on Electrical Insulation and Dielectric Phenomena . Roles of cumyl alcohol and crosslinked structure in homo-charge trapping in crosslinked polyethylene . October 2003 . https://ieeexplore.ieee.org/document/1254831 . 213–216 . 10.1109/CEIDP.2003.1254831. 0-7803-7910-1 . 137379755 .
  9. Gulmine . J. V. . Akcelrud . L. . 2006-10-01 . FTIR characterization of aged XLPE . Polymer Testing . en . 25 . 7 . 932–942 . 10.1016/j.polymertesting.2006.05.014 . 0142-9418.
  10. Chen . Meng . Zhang . Hongliang . Wang . Yalin . Wu . Jiandong . Yin . Yi . February 2020 . Space charge dynamics of acetophenone and cumyl alcohol and their synergistic effect in LDPE . . 27 . 1 . 67–75 . 10.1109/TDEI.2019.008320 . 211119082 . 1070-9878.
  11. Hussin . N. . Chen . G. . February 2012 . Analysis of space charge formation in LDPE in the presence of crosslinking byproducts . . 19 . 1 . 126–133 . 10.1109/TDEI.2012.6148510 . 31136608 . 1070-9878.
  12. Web site: cuminyl alcohol, 536-60-7 . 2023-03-29 . www.thegoodscentscompany.com . en-US.
  13. Web site: p-Cymen-7-ol . 2023-03-29 . webbook.nist.gov . en.
  14. Web site: Cumic alcohol CAS#536-60-7 insulinotropic agent MedKoo . 2023-03-29 . medkoo.com.
  15. Web site: cuminyl alcohol, 536-60-7 . 2023-03-29 . www.thegoodscentscompany.com . en-US.
  16. Api . A.M. . Belsito . D. . Biserta . S. . Botelho . D. . Bruze . M. . Burton . G.A. . Buschmann . J. . Cancellieri . M.A. . Dagli . M.L. . Date . M. . Dekant . W. . Deodhar . C. . Fryer . A.D. . Gadhia . S. . Jones . L. . July 2020 . RIFM fragrance ingredient safety assessment, p-isopropylbenzyl alcohol, CAS Registry Number 536-60-7 . Food and Chemical Toxicology . en . 141 . 111338 . 10.1016/j.fct.2020.111338. 32335211 . 216556801 .
  17. Patil . Swapnil B. . Takalikar . Shreehari S. . Joglekar . Madhav M. . Haldavnekar . Vivek S. . Arvindekar . Akalpita U. . October 2013 . Insulinotropic and β-cell protective action of cuminaldehyde, cuminol and an inhibitor isolated from Cuminum cyminum in streptozotocin-induced diabetic rats . British Journal of Nutrition . en . 110 . 8 . 1434–1443 . 10.1017/S0007114513000627 . 23507295 . 0007-1145. free .
  18. Ali . Mohd Sajid . Rehman . Md Tabish . Al-Lohedan . Hamad A. . AlAjmi . Mohamed Fahad . 2022-12-12 . Exploration of the binding between cuminol and bovine serum albumin through spectroscopic, molecular docking and molecular dynamics methods . Journal of Biomolecular Structure and Dynamics . 40 . 22 . 12404–12412 . 10.1080/07391102.2021.1971560 . 0739-1102 . 34488560. 237432888 .

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